T-01
MOTS-c reconstitution calculator
Concentration, per-dose volume, U-100 syringe units and doses per vial from stated vial size, diluent volume and dose mass. Vial strength is treated as user-asserted because no approved label exists.
Concentration, per-dose volume, U-100 syringe units and doses per vial from stated vial size, diluent volume and dose mass. Vial strength is treated as user-asserted because no approved label exists.
Results
- Concentration
- 2.5 mg/mL2500 mcg/mL
- Volume per dose
- 0.1 mL
- U-100 syringe units per dose
- 10 unitsFits the 1 mL barrel (100 unit scale).
- Full doses per vial
- 20 doses
Every reconstitution calculator starts from the milligrams stated on a vial. For an approved drug that number is on an FDA-reviewed label. For MOTS-c there is no approved product and no United States Pharmacopeia monograph, so the number comes from a supplier's own printing. FDA reviewed certificates of analysis for MOTS-c and found no impurity limits, no aggregate testing and no endotoxin or bioburden results, and concluded both the free base and the acetate salt are not well-characterized. It also warns that multiple salts and derivatives, including different active moieties, are sold under the same common name. This tool therefore computes arithmetic on a number you assert, and labels its output as arithmetic rather than as a dose.
Arithmetic only: concentration = vial mg / water mL; units = mL x 100. It does not check any dose against any reference.
Worked example
Worked example
A vial printed 5 mg with 2 mL of bacteriostatic water gives 5 / 2 = 2.5 mg/mL (2500 mcg/mL). A 250 mcg draw is 0.25 mg; 0.25 / 2.5 = 0.1 mL. 0.1 mL on a U-100 insulin syringe is 0.1 x 100 = 10 units. A 5 mg vial contains 5000 mcg, so 5000 / 250 = 20 full draws. Every step above is arithmetic on the number printed on the vial. Nothing in this example says that 250 mcg is a dose anyone should use, because no such number has ever been established for MOTS-c in humans.
Frequently asked questions
Why does the calculator not suggest a dose?
Because none exists to suggest. No human dose-finding study of MOTS-c has been published, no pharmacokinetic study exists in any species, and FDA reports that the animal work never established a dose-response relationship. The tool documents arithmetic for the value you enter; it does not validate that value.
Can I convert the mouse doses into a human dose?
No, and this site will not print a conversion. Body-surface-area scaling assumes you know how a compound behaves once it is in the body. For MOTS-c that data does not exist in any species: no half-life, no bioavailability, no dose-exposure curve.
Why is vial strength called an assumption?
Because there is no approved label or pharmacopeial monograph behind it. FDA reviewed MOTS-c certificates of analysis and found no impurity, aggregate, endotoxin or bioburden data, concluded the substance is not well-characterized, and warned that different salts and derivatives are sold under the same name. The millig
Because there is no approved label or pharmacopeial monograph behind it. FDA reviewed MOTS-c certificates of analysis and found no impurity, aggregate, endotoxin or bioburden data, concluded the substance is not well-characterized, and warned that different salts and derivatives are sold under the same name. The milligram figure is a supplier's claim.
What do the units on an insulin syringe mean?
U-100 syringes mark 100 units per mL, so 1 unit is 0.01 mL. Units measure volume, not peptide mass; the mass per unit depends entirely on your concentration.
Why does the study explorer show species and molecule on every row?
Because those two columns are where the truth lives in this compound's literature. A mouse dose is mouse data, a CB4211 dose belongs to a different molecule, and a study that measured your own MOTS-c gave nothing to anyone. The explorer never merges them.
Tools: educational calculators and references only.